There is a lack of research exploring the relationship between different symptom profiles in people with bipolar disorder and suicide risk. To address this, using data from the National Network of Depression Centers Mood Outcomes Program, we explored the various factors that can either strengthen or weaken the association between symptoms of depression, mania, mixed mood, and suicidal thoughts or behaviors in 6,105 patients (998 with bipolar disorder and 5,117 with major depression).

Calculating someone’s risk of having repeated manic or depressive episodes is an important part of treatment for Bipolar Disorder. This kind of information allows clinicians to develop tailored treatment plans for their patients. In this article, we explored whether a risk calculator to identify the likelihood of repeated manic or depressive episodes in youth and young adults could be used with adult patients.